litaba

E ipapisitse le skeleton ea aza-BODIPY, NIR1001 e kenyelletsa lihlopha tse fanang ka li-elektronike (mohlala, 4-N,N-diphenylaminophenyl) sebakeng sa 2,6-positions, ho etsa sebopeho sa D-π-D sa symmetric1. Moralo ona o fokotsa lekhalo la HOMO-LUMO, o fetola tlhoro ea ho monya ho feta 1000 nm le ho ntlafatsa phetisetso ea intramolecular charge (ICT). Ho THF, NIR1001 e bonts'a karolo e kholo ea ho monya lifoto tse peli (TPA) ea 37 GM, ntlafatso e habeli ho feta tse nkiloeng ho BODIPY ea setso. Bophelo ba eona ba boemo bo thabileng ba 1.2 ps bo nolofalletsa liphetoho tse sa sebeliseng mahlaseli a kotsi, e leng ho etsang hore e tšoanelehe bakeng sa phekolo ea photodynamic (PDT).

Lipalo tsa DFT li senola hore mokhoa oa phetisetso ea litefiso oa NIR1001 o hlaha ho tloha ho π-electron delocalization pakeng tsa lihlopha tsa bafani le ba amohelang. Phetoho ea Methoxy e boetse e ntlafatsa ho kenngoa ha NIR ka fensetere ea phototherapeutic (650-900 nm), e ntlafatsa kutloisiso1. Ha ho bapisoa le lidae tsa AF tsa Fudan University, NIR1001 e boloka boima ba molek'hule e nyane (<500 Da) ka 40% e phahameng ea ho nka lifoto. Phetoho ea carboxylation e ntlafatsa ho qhibiliha ha metsi (cLogD = 1.2), ho fokotsa ho ba le adsorption e sa tobang lits'ebetsong tsa baeloji.

3. Lisebelisoa tsa Biomedical
Ka bioimaging, hCG-conjugated probe hCG-NIR1001 e finyella litšoantšo tse phahameng tsa li-follicle tsa mahe a bomme le li-micro-metastases tlas'a 808 nm excitation. Ka botebo ba ho kenella ka 3 cm ho NIR-II, e feta liphuputso tsa NIR-I ka makhetlo a mararo, ha e ntse e fokotsa fluorescence e ka morao ka 60%. Mohlala oa kotsi ea renal ea mouse, NIR1001 e bonts'a 85% e khethehileng ea renal, e lemoha tšenyo ka makhetlo a tšeletseng ka potlako ho feta taolo ea macromolecular.
Bakeng sa PDT, NIR1001 e hlahisa mefuta ea oksijene e sebetsang (ROS) ho 0.85 μmol/J tlas'a 1064 nm laser irradiation, ka katleho e kenyang tumor cell apoptosis. Liposome-encapsulated NIR1001 nanoparticles (NPs) e bokella makhetlo a 7.2 ka har'a lihlahala ho feta dae e sa lefelloeng, e fokotsang liphello tse sa lebelloang.
4. Tlhokomelo ea Liindasteri le Tikoloho
Lits'ebetsong tsa indasteri, NIR1001 e kenyelelitsoe ho analyzer ea Juhang Technology's SupNIR-1000 bakeng sa ho hlopha litholoana, tlhahlobo ea boleng ba nama le ts'ebetso ea koae. E sebetsa ka har'a mefuta ea 900-1700 nm, ka nako e le 'ngoe e lekanya boemo ba tsoekere, mongobo le masala a chefo e bolaeang likokoanyana ka har'a metsotsoana e 30 ka ho nepahala ha ±(50ppm+5%). Ka li-sensor tsa likoloi tsa CO2 (ACDS-1001), NIR1001 e nolofalletsa ho shebella ka nako ea sebele ka nako ea karabelo ea T90≤25s le nako ea lilemo tse 15.
Bakeng sa ho lemoha tikoloho, li-probe tse sebetsang tsa NIR1001 li fumana litšepe tse boima ka metsing. Ho pH 6.5-8.0, matla a fluorescence a tsamaellana hantle le Hg²⁺ concentration (0.1-10 μM) e nang le moeli oa ho lemoha oa 0.05 μM, mekhoa ea colorimetric e sebetsang hantle ka liodara tse peli tsa boholo.
5. Boqapi ba Theknoloji le Khoebo
Lisebelisoa tsa Qingdao Topwelle sebelisa motsoako o tsoelang pele ho hlahisa NIR1001 ho 99.5% bohloeki, ka matla a 50 kg / batch. U sebelisa li-microchannel reactors, nako ea condensation ea Knoevenagel e fokotsehile ho tloha ho lihora tse 12 ho isa ho metsotso e 30, e fokotsa tšebeliso ea matla ka 60%. Letoto la ISO 13485-certified NIR1001 le laola 'maraka oa biomedical.